The EED protein–protein interaction inhibitor A-395 inactivates the PRC2 complex

Yupeng He, Sujatha Selvaraju, Michael L. Curtin, +34

Nature Chemical Biology

Protein FunctionSignal TransductionMolecular RegulationPrc2 ComplexMolecular Biology +5

Discovery and Development of Potent and Selective Inhibitors of Histone Methyltransferase G9a

Ramzi F. Sweis, Marina Pliushchev, Peter J. Brown, +10

ACS Medicinal Chemistry Letters

Histone ModificationsEpigenetic ChangeGeneticsMolecular BiologySelective Inhibitors +16

The Histone Methyltransferase Inhibitor A-366 Uncovers a Role for G9a/GLP in the Epigenetics of Leukemia

William N. Pappano, Jun Guo, Yupeng He, +12

PLoS ONE

Histone ModificationsEpigenetic ChangeGeneticsMixed-phenotype Acute LeukemiaHistone Methyltransferases +15

Discovery and Metabolic Stabilization of Potent and Selective 2-Amino-<i>N</i>-(adamant-2-yl) Acetamide 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors

Jeffrey J. Rohde, Marina Pliushchev, Bryan K. Sorensen, +24

Journal of Medicinal Chemistry

Medicinal ChemistryPharmacological StudyBiochemistryMedicineNatural Sciences +9

The synthesis and biological evaluation of a novel series of antimicrobials of the oxazolidinone class

Richard J. Sciotti, Marina Pliushchev, Paul E. Wiedeman, +8

Bioorganic & Medicinal Chemistry Letters

Antifungal AgentBioorganic ChemistryNovel SeriesMedicineDrug Discovery +7

Synthesis of N-arylated oxazolidinones via a palladium catalyzed cross coupling reaction. Application to the synthesis of the antibacterial agent Dup-721

David J. Madar, Hana Kopecka, Daisy Pireh, +5

Tetrahedron Letters

Cross-coupling ReactionEngineeringOrganic ChemistryCatalysisChemistry +5

Discovery of adamantane ethers as inhibitors of 11β-HSD-1: Synthesis and biological evaluation

Jyoti Patel, Shuai Qi, Jürgen Dinges, +21

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBioorganic ChemistryBiochemistryNatural SciencesMedicine +9

SAR of amino pyrrolidines as potent and novel protein-protein interaction inhibitors of the PRC2 complex through EED binding

Michael L. Curtin, Marina Pliushchev, Huan‐Qiu Li, +18

Bioorganic & Medicinal Chemistry Letters

BiochemistryEed BindingMedicineNatural SciencesPrc2 Complex +9

SAR and characterization of non-substrate isoindoline urea inhibitors of nicotinamide phosphoribosyltransferase (NAMPT)

Michael L. Curtin, H. Robin Heyman, Richard F. Clark, +30

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryPharmaceutical ScienceBiochemistryNatural SciencesMedicine +7

Superoxide produced by mitochondrial site IQ inactivates cardiac succinate dehydrogenase and induces hepatic steatosis in Sod2 knockout mice

Hoi Shan Wong, Vojtěch Mezera, Pratiksha Dighe, +9

Free Radical Biology and Medicine