3,5-Bis(trifluoromethyl)pyrazoles:  A Novel Class of NFAT Transcription Factor Regulator

Stevan W. Djurić, Nwe Y. BaMaung, Anwer Basha, +26

Journal of Medicinal Chemistry

Molecular RegulationImmunologyPharmacotherapyChemical BiologyPharmaceutical Chemistry +16

Potent Inhibition of NFAT Activation and T Cell Cytokine Production by Novel Low Molecular Weight Pyrazole Compounds

James M. Trevillyan, X. Grace Chiou, Yung‐Wu Chen, +13

Journal of Biological Chemistry

Dipeptidyl peptidase IV inhibitors for the treatment of impaired glucose tolerance and type 2 diabetes.

Paul E. Wiedeman, James M. Trevillyan

PubMed

GlycobiologyPharmacotherapyInsulin SignalingGastrointestinal Peptide HormoneDrug Resistance +15

Discovery, Structure−Activity Relationship, and Pharmacological Evaluation of (5-Substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as Potent Dipeptidyl Peptidase IV Inhibitors

Zhonghua Pei, Xiaofeng Li, Kenton L. Longenecker, +23

Journal of Medicinal Chemistry

Medicinal ChemistryPharmaceutical ScienceBiochemistryAffect PotencyStructure−activity Relationship +12

The synthesis and biological evaluation of a novel series of antimicrobials of the oxazolidinone class

Richard J. Sciotti, Marina Pliushchev, Paul E. Wiedeman, +8

Bioorganic & Medicinal Chemistry Letters

Antifungal AgentBioorganic ChemistryNovel SeriesMedicineDrug Discovery +7

Synthesis of N-arylated oxazolidinones via a palladium catalyzed cross coupling reaction. Application to the synthesis of the antibacterial agent Dup-721

David J. Madar, Hana Kopecka, Daisy Pireh, +5

Tetrahedron Letters

Cross-coupling ReactionEngineeringOrganic ChemistryCatalysisChemistry +5

(+)-Pleuromutilin synthetic studies. Degradative and de novo acquisition of a levorotatory tricyclic lactone subunit

Leo A. Paquette, Paul E. Wiedeman, Philip C. Bulman Page

The Journal of Organic Chemistry

BiosynthesisBioorganic ChemistryEngineeringBiochemistry-Pleuromutilin Synthetic Studies +10

Crystal Structures of DPP-IV (CD26) from Rat Kidney Exhibit Flexible Accommodation of Peptidase-Selective Inhibitors

Kenton L. Longenecker, Kent D. Stewart, David J. Madar, +15

Biochemistry

Glucagon-like PeptideChemical BiologyMedicinal ChemistryActive Site ArchitectureBiochemistry +14

Discovery of 2-[4-{{2-(2<i>S</i>,5<i>R</i>)-2-Cyano-5-ethynyl-1-pyrrolidinyl]-2-oxoethyl]amino]- 4-methyl-1-piperidinyl]-4-pyridinecarboxylic Acid (ABT-279):  A Very Potent, Selective, Effective, and Well-Tolerated Inhibitor of Dipeptidyl Peptidase-IV, Useful for the Treatment of Diabetes

David J. Madar, Hana Kopecka, Daisy Pireh, +28

Journal of Medicinal Chemistry

Inhibition of p56lckTyrosine Kinase by Isothiazolones

James M. Trevillyan, X. Grace Chiou, Stephen J. Ballaron, +15

Archives of Biochemistry and Biophysics

Medicinal ChemistryBiochemistryMedicineNatural SciencesMechanism Of Action +6