James M. Trevillyan

The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes.

Christopher E. Rudd, James M. Trevillyan, J D Dasgupta et al. · Proceedings of the National Academy of Sciences · 1988 · 720 citations · Full text

Life Sciences, Cell Biology, Immunology +13

The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex.

Elizabeth K. Barber, J D Dasgupta, Stuart F. Schlossman et al. · Proceedings of the National Academy of Sciences · 1989 · 456 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14

PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice

Bradley A. Zinker, Cristina M. Rondinone, James M. Trevillyan et al. · Proceedings of the National Academy of Sciences · 2002 · 416 citations

Life Sciences, Endocrinology, Molecular Biology +17

Discovery of a Potent, Selective Protein Tyrosine Phosphatase 1B Inhibitor Using a Linked-Fragment Strategy

Bruce G. Szczepankiewicz, Gang Liu, Philip J. Hajduk et al. · Journal of the American Chemical Society · 2003 · 228 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Reduction of Protein Tyrosine Phosphatase 1B Increases Insulin-Dependent Signaling in <i>ob/ob</i> Mice

Rebecca J. Gum, Lori L. Gaede, Sandra Koterski et al. · Diabetes · 2003 · 198 citations · Full text

Life Sciences, Biochemistry, Endocrinology +17