Bruce G. Szczepankiewicz

Discovery of a Potent, Selective Protein Tyrosine Phosphatase 1B Inhibitor Using a Linked-Fragment Strategy

Bruce G. Szczepankiewicz, Gang Liu, Philip J. Hajduk et al. · Journal of the American Chemical Society · 2003 · 226 citations · Full text

Type Ii Diabetes, Drug Target, Biochemistry +15

SIRT1 Activation by Small Molecules

Han Dai, Lauren Kustigian, David P. Carney et al. · Journal of Biological Chemistry · 2010 · 213 citations · Full text

Protein Function, Signal Transduction, Cell Regulation +15

Crystallographic structure of a small molecule SIRT1 activator-enzyme complex

Han Dai, April Case, Thomas V. Riera et al. · Nature Communications · 2015 · 197 citations · Full text

Aminopyridine-Based c-Jun N-Terminal Kinase Inhibitors with Cellular Activity and Minimal Cross-Kinase Activity

Bruce G. Szczepankiewicz, Christi Kosogof, Lissa T.J. Nelson et al. · Journal of Medicinal Chemistry · 2006 · 159 citations · Full text

Little Inhibitory Activity, Drug Target, Pharmacotherapy +21

Selective Protein Tyrosine Phosphatase 1B Inhibitors:  Targeting the Second Phosphotyrosine Binding Site with Non-Carboxylic Acid-Containing Ligands

Gang Liu, Zhili Xin, Heng Liang et al. · Journal of Medicinal Chemistry · 2003 · 106 citations · Full text

Drug Target, Chemical Biology, Receptor Tyrosine Kinase +16