Activation of latent myostatin by the BMP-1/tolloid family of metalloproteinases

Neil M. Wolfman, Alexandra C. McPherron, William N. Pappano, +8

Proceedings of the National Academy of Sciences

Mammalian BMP-1/Tolloid-Related Metalloproteinases, Including Novel Family Member Mammalian Tolloid-Like 2, Have Differential Enzymatic Activities and Distributions of Expression Relevant to Patterning and Skeletogenesis

Ian C. Scott, Ira L. Blitz, William N. Pappano, +8

Developmental Biology

InflammationToll-like ReceptorsMolecular ImmunologyImmunogeneticsDifferential Enzymatic Activities +7

Multiple Bone Morphogenetic Protein 1-related Mammalian Metalloproteinases Process Pro-lysyl Oxidase at the Correct Physiological Site and Control Lysyl Oxidase Activation in Mouse Embryo Fibroblast Cultures

Mehmet Üzel, Ian C. Scott, Hermik Babakhanlou‐Chase, +5

Journal of Biological Chemistry

The EED protein–protein interaction inhibitor A-395 inactivates the PRC2 complex

Yupeng He, Sujatha Selvaraju, Michael L. Curtin, +34

Nature Chemical Biology

Protein FunctionSignal TransductionMolecular RegulationPrc2 ComplexMolecular Biology +5

Homologues of Twisted gastrulation are extracellular cofactors in antagonism of BMP signalling

Ian C. Scott, Ira L. Blitz, William N. Pappano, +3

Nature

Signal TransductionSignaling PathwayNatural SciencesMolecular BiologyIntercellular Communication +7

Discovery and Development of Potent and Selective Inhibitors of Histone Methyltransferase G9a

Ramzi F. Sweis, Marina Pliushchev, Peter J. Brown, +10

ACS Medicinal Chemistry Letters

Histone ModificationsEpigenetic ChangeGeneticsMolecular BiologySelective Inhibitors +16

Bone Morphogenetic Protein-1 Processes Probiglycan

Ian C. Scott, Yasutada Imamura, William N. Pappano, +4

Journal of Biological Chemistry

Sonic hedgehog function in chondrichthyan fins and the evolution of appendage patterning

Randall D. Dahn, Marcus C. Davis, William N. Pappano, +1

Nature

BiologyPattern FormationDevelopmental BiologyChondrichthyan FinsSonic Hedgehog Function +6

Mammalian Tolloid Metalloproteinase, and Not Matrix Metalloprotease 2 or Membrane Type 1 Metalloprotease, Processes Laminin-5 in Keratinocytes and Skin

Dallas P. Veitch, Pasi Nokelainen, Kelly A. McGowan, +9

Journal of Biological Chemistry

Matrix Metalloprotease 2ImmunologyDermatologyCellular PhysiologyInflammation +18

The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity

Kenneth D. Bromberg, Taylor R. H. Mitchell, Anup K. Upadhyay, +28

Nature Chemical Biology

ChromatinChromatin RemodelingEpigenetic ChangeGeneticsGenomic Integrity +8