Stephen V. Frye

Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

Wei Xu, Hui Yang, Ying Liu et al. · Cancer Cell · 2011 · 2.8K citations · Full text

Molecular Pharmacology, Aldehyde Dehydrogenase, Biochemistry +4

The promise and peril of chemical probes

C.H. Arrowsmith, James E. Audia, Christopher P. Austin et al. · Nature Chemical Biology · 2015 · 836 citations · Full text

Dynamic Reprogramming of the Kinome in Response to Targeted MEK Inhibition in Triple-Negative Breast Cancer

John S. Duncan, Martin C. Whittle, Kazuhiro Nakamura et al. · Cell · 2012 · 732 citations · Full text

Breast Oncology, Medicine, Receptor Tyrosine Kinase +11

A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells

Masoud Vedadi, Dalia Baršytė-Lovejoy, Feng Liu et al. · Nature Chemical Biology · 2011 · 527 citations

Signal Transduction, Cellular Enzymology, Biochemistry +12

An Orally Bioavailable Chemical Probe of the Lysine Methyltransferases EZH2 and EZH1

Kyle D. Konze, Anqi Ma, Fengling Li et al. · ACS Chemical Biology · 2013 · 464 citations · Full text

Histone Modifications, Epigenetic Change, Molecular Biology +20