Kyle D. Konze - Concepedia

Author

Kyle D. Konze

Schrodinger (United States)

Also Known As

Huang, Xi Ping, Konze, Kyle, Konze, Kyle D., Kyle D. Konze, Kyle Konze, Simon, Jeremy M.

Publications

1.3K

Citations

H-Index

Concepts

All Affiliations

Schrodinger (United States)Structural Genomics Consortium University of Toronto University of North Carolina at Chapel Hill Icahn School of Medicine at Mount Sinai

About

Kyle D. Konze is an author at Schrodinger (United States) specializing in medicine, drug discovery, and biochemistry.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Medicine	4	4	622
2	Natural Sciences	3	3	611
3	Biochemistry	3	3	611
4	Engineering	1	1	11
5	Cell Biology	1	1	464

Kyle D. Konze

Publications

1.1K

Citations

H-Index

Page 1

	Year	Citations
An Orally Bioavailable Chemical Probe of the Lysine Methyltransferases EZH2 and EZH1 Kyle D. Konze, Anqi Ma, Fengling Li, ACS Chemical Biology Histone ModificationsEpigenetic ChangeMolecular BiologyChemical BiologyCancer Biology	2013	464
Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia Bowen Xu, Doan M. On, Anqi Ma, Blood	2014	228
Reaction-Based Enumeration, Active Learning, and Free Energy Calculations To Rapidly Explore Synthetically Tractable Chemical Space and Optimize Potency of Cyclin-Dependent Kinase 2 Inhibitors Kyle D. Konze, Pieter H. Bos, Markus K. Dahlgren, Journal of Chemical Information and Modeling	2019	135
Selective Inhibitors of Protein Methyltransferases H. Ümit Kanıskan, Kyle D. Konze, Jian Jin Journal of Medicinal Chemistry Histone ModificationsTarget PmtsDrug TargetEpigenetic ChangeMolecular Biology	2014	127
Structure–Activity Relationship Studies for Enhancer of Zeste Homologue 2 (EZH2) and Enhancer of Zeste Homologue 1 (EZH1) Inhibitors Xiaobao Yang, Fengling Li, Kyle D. Konze, Journal of Medicinal Chemistry	2016	59
Combining Cloud-Based Free-Energy Calculations, Synthetically Aware Enumerations, and Goal-Directed Generative Machine Learning for Rapid Large-Scale Chemical Exploration and Optimization Phani Ghanakota, Pieter H. Bos, Kyle D. Konze, Journal of Chemical Information and Modeling	2020	53
A Chemical Tool for In Vitro and In Vivo Precipitation of Lysine Methyltransferase G9a Kyle D. Konze, Samantha G. Pattenden, Feng Liu, ChemMedChem	2014	31
Reaction-based Enumeration, Active Learning, and Free Energy Calculations to Rapidly Explore Synthetically Tractable Chemical Space and Optimize Potency of Cyclin Dependent Kinase 2 Inhibitors Kyle D. Konze, Pieter H. Bos, Markus K. Dahlgren, Hit IdentificationComputational ChemistryChemical BiologyPharmaceutical ChemistryMolecular Design	2019	20
Combining Cloud-Based Free Energy Calculations, Synthetically Aware Enumerations and Goal-Directed Generative Machine Learning for Rapid Large-Scale Chemical Exploration and Optimization Phani Ghanakota, Pieter H. Bos, Kyle D. Konze, Artificial IntelligenceEngineeringMachine LearningHit IdentificationMachine Learning Tool	2020	11

Page 1