John Zevenhoven

High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs

Sven Rottenberg, Janneke E. Jaspers, Ariena Kersbergen et al. · Proceedings of the National Academy of Sciences · 2008 · 943 citations · Full text

Breast Oncology, Pathology, Cancer Biology +17

Induction of small cell lung cancer by somatic inactivation of both Trp53 and Rb1 in a conditional mouse model

Ralph Meuwissen, Sabine C. Linn, R. Ilona Linnoila et al. · Cancer Cell · 2003 · 638 citations · Full text

Oncogenic Agent, Medicine, Conditional Mouse Model +12

Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB

Sirith Douma, Theo van Laar, John Zevenhoven et al. · Nature · 2004 · 610 citations · Full text

Signal Transduction, Tumor Innervation, Tumor Microenvironment +12

Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis

Patrick W.B. Derksen, Xiaoling Liu, Francis N. Saridin et al. · Cancer Cell · 2006 · 590 citations · Full text

Breast Oncology, Anoikis Resistance, Mice Leads +9

Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human <i>BRCA1</i> -mutated basal-like breast cancer

Xiaoling Liu, Henne Holstege, Hanneke van der Gulden et al. · Proceedings of the National Academy of Sciences · 2007 · 475 citations · Full text