Ariena Kersbergen

High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs

Sven Rottenberg, Janneke E. Jaspers, Ariena Kersbergen et al. · Proceedings of the National Academy of Sciences · 2008 · 943 citations · Full text

Breast Oncology, Pathology, Cancer Biology +17

An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer

Marian L. Burr, Christina E. Sparbier, Kah Lok Chan et al. · Cancer Cell · 2019 · 596 citations · Full text

REV7 counteracts DNA double-strand break resection and affects PARP inhibition

Guotai Xu, J. Ross Chapman, Inger Brandsma et al. · Nature · 2015 · 583 citations · Full text

Chromatin, Genome Instability, Parp Inhibition +6

Loss of 53BP1 Causes PARP Inhibitor Resistance in <i>Brca1</i> -Mutated Mouse Mammary Tumors

Janneke E. Jaspers, Ariena Kersbergen, Ute Boon et al. · Cancer Discovery · 2012 · 510 citations · Full text

Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality

Ewa Gogola, Alexandra A. Duarte, Julian R. de Ruiter et al. · Cancer Cell · 2018 · 379 citations · Full text

Parg Restores Parylation, Selective Loss, Medicine +4