High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs

Sven Rottenberg, Janneke E. Jaspers, Ariena Kersbergen, +13

Proceedings of the National Academy of Sciences

Breast OncologyPathologyCancer BiologyPlatinum DrugsTumor Biology +15

REV7 counteracts DNA double-strand break resection and affects PARP inhibition

Guotai Xu, J. Ross Chapman, Inger Brandsma, +27

Nature

ChromatinGenome InstabilityParp InhibitionNatural SciencesMolecular Biology +4

Loss of 53BP1 Causes PARP Inhibitor Resistance in <i>Brca1</i> -Mutated Mouse Mammary Tumors

Janneke E. Jaspers, Ariena Kersbergen, Ute Boon, +16

Cancer Discovery

Reversible Epithelial to Mesenchymal Transition and Acquired Resistance to Sunitinib in Patients with Renal Cell Carcinoma: Evidence from a Xenograft Study

Hans J. Hammers, Henk M.W. Verheul, Brenda Salumbides, +11

Molecular Cancer Therapeutics

UrologyOncologyAcquired ResistanceGenitourinary CancerMedicine +13

IL-18–secreting CAR T cells targeting DLL3 are highly effective in small cell lung cancer models

Janneke E. Jaspers, Jonathan F. Khan, William D. Godfrey, +4

Journal of Clinical Investigation

Selective resistance to the PARP inhibitor olaparib in a mouse model for BRCA1-deficient metaplastic breast cancer

Linda Henneman, Martine H. van Miltenburg, Ewa M. Michalak, +13

Proceedings of the National Academy of Sciences

6-Thioguanine Selectively Kills BRCA2-Defective Tumors and Overcomes PARP Inhibitor Resistance

Natalia Issaeva, Huw D. Thomas, Tatjana Djurenovic, +17

Cancer Research

Brca2 GenesGenome InstabilityMedicinePharmacologyPathology +12

The PARP Inhibitor AZD2461 Provides Insights into the Role of PARP3 Inhibition for Both Synthetic Lethality and Tolerability with Chemotherapy in Preclinical Models

Lenka Oplustil O’Connor, Stuart L. Rulten, Aaron Cranston, +16

Cancer Research

Chemoprevention StrategyParp3 InhibitionPharmacotherapyCancer BiologyTumor Biology +20

Sensitivity and Acquired Resistance of BRCA1;p53-Deficient Mouse Mammary Tumors to the Topoisomerase I Inhibitor Topotecan

Serge A.L. Zander, Ariena Kersbergen, Eline van der Burg, +9

Cancer Research

Breast OncologyAcquired ResistanceCombination Topotecan-olaparibMedicinePathology +12

Impaired Endothelial Progenitor Cell Mobilization and Dysfunctional Bone Marrow Stroma in Diabetes Mellitus

Peter E. Westerweel, Martin Teraa, Shahin Rafii, +5

PLoS ONE