Toshifumi Kimura

Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents

Hiroshi Hirai, Yoshikazu Iwasawa, Megumu Okada et al. · Molecular Cancer Therapeutics · 2009 · 540 citations

Wee1 Kinase, Oncogenic Agent, Medicine +15

Discovery and in vitro and in vivo profiles of 4-fluoro-N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-methylbenzamide as novel class of an orally active metabotropic glutamate receptor 1 (mGluR1) antagonist

Atsushi Satoh, Yasushi Nagatomi, Yukari Hirata et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 102 citations · Full text

Vivo Profiles, Biochemistry, Functional Selectivity +8

Pharmacological Effects of the Metabotropic Glutamate Receptor 1 Antagonist Compared with Those of the Metabotropic Glutamate Receptor 5 Antagonist and Metabotropic Glutamate Receptor 2/3 Agonist in Rodents: Detailed Investigations with a Selective Allosteric Metabotropic Glutamate Receptor 1 Antagonist, FTIDC [4-[1-(2-Fluoropyridine-3-yl)-5-methyl-1 H-1,2,3-triazol-4-yl]-N-isopropyl-N-methyl-3,6-dihydropyridine-1(2 H)-carboxamide]

Akio Satow, Shunsuke Maehara, Satoko Ise et al. · Journal of Pharmacology and Experimental Therapeutics · 2008 · 72 citations

Pharmacological Characterization of a New, Orally Active and Potent Allosteric Metabotropic Glutamate Receptor 1 Antagonist, 4-[1-(2-Fluoropyridin-3-yl)-5-methyl-1 H-1,2,3-triazol-4-yl]-N-isopropyl-N-methyl-3,6-dihydropyridine-1(2 H)-carboxamide (FTIDC)

Gentaroh Suzuki, Toshifumi Kimura, Akio Satow et al. · Journal of Pharmacology and Experimental Therapeutics · 2007 · 67 citations

Discovery and biological profile of isoindolinone derivatives as novel metabotropic glutamate receptor 1 antagonists: A potential treatment for psychotic disorders

Satoru Ito, Yukari Hirata, Yasushi Nagatomi et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 62 citations · Full text

Psychoactive Drug, Psychiatry, Functional Selectivity +13