Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents

Hiroshi Hirai, Yoshikazu Iwasawa, Megumu Okada, +20

Molecular Cancer Therapeutics

Wee1 KinaseOncogenic AgentMedicineTyrosine KinaseReceptor Tyrosine Kinase +13

Discovery and in vitro and in vivo profiles of 4-fluoro-N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-methylbenzamide as novel class of an orally active metabotropic glutamate receptor 1 (mGluR1) antagonist

Atsushi Satoh, Yasushi Nagatomi, Yukari Hirata, +9

Bioorganic & Medicinal Chemistry Letters

Vivo ProfilesBiochemistryFunctional SelectivityMedicineMechanism Of Action +6

Pharmacological Effects of the Metabotropic Glutamate Receptor 1 Antagonist Compared with Those of the Metabotropic Glutamate Receptor 5 Antagonist and Metabotropic Glutamate Receptor 2/3 Agonist in Rodents: Detailed Investigations with a Selective Allosteric Metabotropic Glutamate Receptor 1 Antagonist, FTIDC [4-[1-(2-Fluoropyridine-3-yl)-5-methyl-1 H-1,2,3-triazol-4-yl]-N-isopropyl-N-methyl-3,6-dihydropyridine-1(2 H)-carboxamide]

Akio Satow, Shunsuke Maehara, Satoko Ise, +8

Journal of Pharmacology and Experimental Therapeutics

Pharmacological Characterization of a New, Orally Active and Potent Allosteric Metabotropic Glutamate Receptor 1 Antagonist, 4-[1-(2-Fluoropyridin-3-yl)-5-methyl-1 H-1,2,3-triazol-4-yl]-N-isopropyl-N-methyl-3,6-dihydropyridine-1(2 H)-carboxamide (FTIDC)

Gentaroh Suzuki, Toshifumi Kimura, Akio Satow, +11

Journal of Pharmacology and Experimental Therapeutics

Discovery and biological profile of isoindolinone derivatives as novel metabotropic glutamate receptor 1 antagonists: A potential treatment for psychotic disorders

Satoru Ito, Yukari Hirata, Yasushi Nagatomi, +9

Bioorganic & Medicinal Chemistry Letters

Psychoactive DrugPsychiatryFunctional SelectivityMedicineBiological Profile +11

Discovery and biological profile of 4-(1-aryltriazol-4-yl)-tetrahydropyridines as an orally active new class of metabotropic glutamate receptor 1 antagonist

Satoru Ito, Atsushi Satoh, Yasushi Nagatomi, +9

Bioorganic & Medicinal Chemistry

Functional SelectivityMedicineBiological ProfileMechanism Of ActionPharmacological Agent +5

J-104129, a novel muscarinic M3 receptor antagonist with high selectivity for M3 over M2 receptors

Morihiro Mitsuya, Toshiaki Mase, Yoshimi Tsuchiya, +10

Bioorganic & Medicinal Chemistry

BiochemistryFunctional SelectivityMedicinePhysiologyMechanism Of Action +6

A Potent, Long-Acting, Orally Active (2<i>R</i>)-2-[(1<i>R</i>)-3,3-Difluorocyclopentyl]-2-hydroxy-2-phenylacetamide:  A Novel Muscarinic M₃ Receptor Antagonist with High Selectivity for M₃ over M₂ Receptors

Morihiro Mitsuya, Kensuke Kobayashi, Kumiko Kawakami, +11

Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryPharmaceutical ChemistryBiochemistryFunctional Selectivity +13

Prevalence and predictors of bipolar disorders in patients with a major depressive episode: The Japanese epidemiological trial with latest measure of bipolar disorder (JET-LMBP)

Takeshi Inoue, Yoshifumi Inagaki, Toshifumi Kimura, +1

Journal of Affective Disorders

Calcium-dependent Conformation of a Mouse Macrophage Calcium-type Lectin

Toshifumi Kimura, Yasuyuki Imai, Tatsuro Irimura

Journal of Biological Chemistry