Yasushi Nagatomi

Discovery and in vitro and in vivo profiles of 4-fluoro-N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-methylbenzamide as novel class of an orally active metabotropic glutamate receptor 1 (mGluR1) antagonist

Atsushi Satoh, Yasushi Nagatomi, Yukari Hirata et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 102 citations · Full text

Vivo Profiles, Biochemistry, Functional Selectivity +8

Discovery and biological profile of isoindolinone derivatives as novel metabotropic glutamate receptor 1 antagonists: A potential treatment for psychotic disorders

Satoru Ito, Yukari Hirata, Yasushi Nagatomi et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 62 citations · Full text

Psychoactive Drug, Psychiatry, Functional Selectivity +13

Concise asymmetric synthesis of a model compound, (4S,5S,6S)-6-(2,2-dimethoxy)ethyl-4,5-epoxy-6-hydroxy-2-cyclohexenone, for the cyclohexenone core of scyphostatin

Hiromichi Fujioka, Naoyuki Kotoku, Yoshinari Sawama et al. · Tetrahedron Letters · 2002 · 61 citations

Enantioselective Synthesis, Engineering, Biochemistry +9

Discovery and biological profile of 4-(1-aryltriazol-4-yl)-tetrahydropyridines as an orally active new class of metabotropic glutamate receptor 1 antagonist

Satoru Ito, Atsushi Satoh, Yasushi Nagatomi et al. · Bioorganic & Medicinal Chemistry · 2008 · 53 citations · Full text

Functional Selectivity, Medicine, Biological Profile +7

Asymmetric Induction via an Intramolecular Haloetherification Reaction of Chiral Ene Acetals:  A Novel Approach to Optically Active 1,4- and 1,5-Diols

Hiromichi Fujioka, H. Kitagawa, Yasushi Nagatomi et al. · The Journal of Organic Chemistry · 1996 · 41 citations

Novel Organocatalysts, Enantioselective Synthesis, Engineering +14