Joseph Duque

Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic

Todd Logan, Matthew Simon, Gerald Maxwell Cherf et al. · Cell · 2021 · 229 citations · Full text

Life Sciences, Genetics, Neuroscience +12

A TREM2-activating antibody with a blood–brain barrier transport vehicle enhances microglial metabolism in Alzheimer’s disease models

Bettina van Lengerich, Lihong Zhan, Dan Xia et al. · Nature Neuroscience · 2023 · 222 citations · Full text

Medicine, Neurobiology, Neuroscience +17

Brain delivery and activity of a lysosomal enzyme using a blood-brain barrier transport vehicle in mice

Julie C. Ullman, Annie Arguello, Jennifer A. Getz et al. · Science Translational Medicine · 2020 · 205 citations

Pharmacy, Neuroscience, Pharmaceutics +17

CD98hc is a target for brain delivery of biotherapeutics

Kylie S. Chew, Robert C. Wells, Arash Moshkforoush et al. · Nature Communications · 2023 · 88 citations · Full text

Pharmacy, Pharmaceutics, Pharmacology +17

Molecular architecture determines brain delivery of a transferrin receptor–targeted lysosomal enzyme

Annie Arguello, Cathal Mahon, Meredith Calvert et al. · The Journal of Experimental Medicine · 2021 · 84 citations · Full text

Pharmacy, Neuroscience, Pharmaceutics +17