Mikio Shirasaki

Discovery of orally efficacious RORγt inverse agonists, part 1: Identification of novel phenylglycinamides as lead scaffolds

Junya Shirai, Yoshihide Tomata, Mitsunori Kono et al. · Bioorganic & Medicinal Chemistry · 2017 · 23 citations · Full text

Medicinal Chemistry, Part 1, Lead Scaffolds +11

Structure-based design, synthesis, and biological evaluation of imidazo[1,2-b]pyridazine-based p38 MAP kinase inhibitors

Akira Kaieda, Masashi Takahashi, Takafumi Takai et al. · Bioorganic & Medicinal Chemistry · 2017 · 21 citations · Full text

Medicinal Chemistry, Biochemistry, Natural Sciences +9

Discovery of orally efficacious RORγt inverse agonists. Part 2: Design, synthesis, and biological evaluation of novel tetrahydroisoquinoline derivatives

Mitsunori Kono, Tsuneo Oda, Michiko Tawada et al. · Bioorganic & Medicinal Chemistry · 2017 · 20 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Biochemistry +11

Amine-free melanin-concentrating hormone receptor 1 antagonists: Novel 1-(1H-benzimidazol-6-yl)pyridin-2(1H)-one derivatives and design to avoid CYP3A4 time-dependent inhibition

Hideyuki Igawa, Masashi Takahashi, Mikio Shirasaki et al. · Bioorganic & Medicinal Chemistry · 2016 · 14 citations · Full text

Cyp3a4 Time-dependent Inhibition, Biochemistry, Functional Selectivity +8

Discovery of Benzofuran Derivatives that Collaborate with Insulin-Like Growth Factor 1 (IGF-1) to Promote Neuroprotection

Takeshi Wakabayashi, Norihito Tokunaga, Kazuyuki Tokumaru et al. · Journal of Medicinal Chemistry · 2016 · 14 citations