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Discovery of orally efficacious RORγt inverse agonists. Part 2: Design, synthesis, and biological evaluation of novel tetrahydroisoquinoline derivatives

Molecular PharmacologyMedicinal ChemistryBiochemistryNovel Tetrahydroisoquinoline DerivativesMedicineNatural SciencesPharmacological AgentPharmacotherapyBiological EvaluationDrug DevelopmentPharmacologyPharmaceutical ChemistryDrug DiscoveryNatural Product Synthesis