Yoshihide Tomata

Discovery of TAK-925 as a Potent, Selective, and Brain-Penetrant Orexin 2 Receptor Agonist

Tatsuhiko Fujimoto, Kentaro Rikimaru, Koichiro Fukuda et al. · ACS Medicinal Chemistry Letters · 2022 · 32 citations · Full text

Asymmetric Total Synthesis of Glycinoeclepin A: Generation of a Novel Bridgehead Anion Species

Yasuhiro Shiina, Yoshihide Tomata, Masaaki Miyashita et al. · Chemistry Letters · 2010 · 28 citations · Full text

Biosynthesis, Glycinoeclepin A, Asymmetric Total Synthesis +10

Discovery of potent, selective, orally active benzoxazepine-based Orexin-2 receptor antagonists

Tatsuhiko Fujimoto, Jun Kunitomo, Yoshihide Tomata et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 28 citations · Full text

Biochemistry, Functional Selectivity, Medicine +5

The first C2 selective halide substitution reaction of 2,3-epoxy alcohols by the use of (CH3O)3B–MX (X=I, Br, Cl) system

Yoshihide Tomata, Minoru Sasaki, Keiji Tanino et al. · Tetrahedron Letters · 2003 · 26 citations

Chemical Engineering, Cross-coupling Reaction, Engineering +6

Identification of novel quinazolinedione derivatives as RORγt inverse agonist

Yoshiyuki Fukase, Ayumu Sato, Yoshihide Tomata et al. · Bioorganic & Medicinal Chemistry · 2017 · 24 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Medicine +7