Divergent synthesis and biological activities of lipid A analogues of shorter acyl chains

Koichi Fukase, Yoshiyuki Fukase, Masato Oikawa, +3

Tetrahedron

Shorter Acyl ChainsBiosynthesisEngineeringBiochemistryLipid A Analogues +4

Discovery of [<i>cis</i>-3-({(5<i>R</i>)-5-[(7-Fluoro-1,1-dimethyl-2,3-dihydro-1<i>H</i>-inden-5-yl)carbamoyl]-2-methoxy-7,8-dihydro-1,6-naphthyridin-6(5<i>H</i>)-yl}carbonyl)cyclobutyl]acetic Acid (TAK-828F) as a Potent, Selective, and Orally Available Novel Retinoic Acid Receptor-Related Orphan Receptor γt Inverse Agonist

Mitsunori Kono, Atsuko Ochida, Tsuneo Oda, +23

Journal of Medicinal Chemistry

PharmacotherapyPharmaceutical ChemistryPre-clinical PharmacologyMolecular PharmacologyMedicinal Chemistry +14

Structural basis for endotoxic and antagonistic activities: investigation with novel synthetic lipid A analogs

Shoichi Kusumoto, Koichi Fukase, Yoshiyuki Fukase, +5

Journal of Endotoxin Research

Lipid PreparationMedicinal ChemistryBiosynthesisBioorganic ChemistryBiochemistry +13

Chemical structure-guided design of dynapyrazoles, cell-permeable dynein inhibitors with a unique mode of action

Jonathan B. Steinman, Cristina Santarossa, Rand M. Miller, +19

eLife

Combinatorial ChemistryUnique ModeMolecular BiologyCytoskeletonMotor Proteins +21

Targeting eIF4A-Dependent Translation of KRAS Signaling Molecules

Kamini Singh, Jianan Lin, Nicolas Lecomte, +23

Cancer Research

Molecular RegulationTumor BiologyDeadly CancerSignaling PathwayCancer Cell Biology +15

Novel Pure αVβ3 Integrin Antagonists That Do Not Induce Receptor Extension, Prime the Receptor, or Enhance Angiogenesis at Low Concentrations

Jihong Li, Yoshiyuki Fukase, Yi Shang, +25

ACS Pharmacology & Translational Science

Structural basis for endotoxic and antagonistic activities: investigation with novel synthetic lipid A analogs

Shoichi Kusumoto, Koichi Fukase, Yoshiyuki Fukase, +5

Journal of Endotoxin Research

Lipid PreparationMedicinal ChemistryBiosynthesisBioorganic ChemistryBiochemistry +13

Synthesis of lipid A and its analogues for investigation of the structural basis for their bioactivity

Yukari Fujimoto, Yo Adachi, Masao Akamatsu, +5

Journal of Endotoxin Research

Lipid AnalysisLipid PreparationBiosynthesisLipid BiophysicsEngineering +12

Discovery of TAK-272: A Novel, Potent, and Orally Active Renin Inhibitor

Yasuhiro Imaeda, Hidekazu Tokuhara, Yoshiyuki Fukase, +7

ACS Medicinal Chemistry Letters

Synthesis of [3H]-Labeled Bioactive Lipid A Analogs and Their Use for Detection of Lipid A-Binding Proteins on Murine Macrophages

Koichi Fukase, Teruo Kirikae, Fumiko Kirikae, +7

Bulletin of the Chemical Society of Japan