Tetsuji Kawamoto

Discovery of [<i>cis</i>-3-({(5<i>R</i>)-5-[(7-Fluoro-1,1-dimethyl-2,3-dihydro-1<i>H</i>-inden-5-yl)carbamoyl]-2-methoxy-7,8-dihydro-1,6-naphthyridin-6(5<i>H</i>)-yl}carbonyl)cyclobutyl]acetic Acid (TAK-828F) as a Potent, Selective, and Orally Available Novel Retinoic Acid Receptor-Related Orphan Receptor γt Inverse Agonist

Mitsunori Kono, Atsuko Ochida, Tsuneo Oda et al. · Journal of Medicinal Chemistry · 2018 · 63 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

Design, Synthesis, and Evaluation of the Highly Selective and Potent G-Protein-Coupled Receptor Kinase 2 (GRK2) Inhibitor for the Potential Treatment of Heart Failure

Tomohiro Okawa, Yoshio Aramaki, Mitsuo Yamamoto et al. · Journal of Medicinal Chemistry · 2017 · 60 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Discovery of TAK-925 as a Potent, Selective, and Brain-Penetrant Orexin 2 Receptor Agonist

Tatsuhiko Fujimoto, Kentaro Rikimaru, Koichiro Fukuda et al. · ACS Medicinal Chemistry Letters · 2022 · 33 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Atropisomeric Flavoenzyme Models with a Modified Pyrimidine Ring:  Syntheses, Physical Properties, and Stereochemistry in the Reactions with NAD(P)H Analogs

Atsuyoshi Ohno, Jun Kunitomo, Yasushi Kawai et al. · The Journal of Organic Chemistry · 1996 · 31 citations

Life Sciences, Biochemistry, Chemistry +13

Synthesis and reaction of novel 5-deazaflavins with axial chirality at pyrimidine ring moiety

Tetsuji Kawamoto, Masaki Tomishima, Fumio Yoneda et al. · Tetrahedron Letters · 1992 · 29 citations

Pharmacy, Chemistry, Medicinal Chemistry +10