Matthew Gill

GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER+ Breast Cancer

Jun Liang, Robert A. Blake, Jae H. Chang et al. · Journal of Medicinal Chemistry · 2021 · 135 citations · Full text

Medicine, Oncology, Pharmacology +15

Identification and optimisation of a series of substituted 5-pyridin-2-yl-thiophene-2-hydroxamic acids as potent histone deacetylase (HDAC) inhibitors

Steve Price, Walter Bordogna, Ruth Braganza et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 33 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12

Identification and optimisation of a series of substituted 5-(1H-pyrazol-3-yl)-thiophene-2-hydroxamic acids as potent histone deacetylase (HDAC) inhibitors

Steve Price, Walter Bordogna, Richard J. Bull et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 30 citations

Pharmacy, Medicinal Chemistry, Pharmacology +13

Identification and hit-to-lead exploration of a novel series of histamine H4 receptor inverse agonists

Sue Cramp, Hazel J. Dyke, Christopher Higgs et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 27 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Modulation of 11β-hydroxysteroid dehydrogenase type 1 activity by 1,5-substituted 1H-tetrazoles

Scott P. Webster, Margaret Binnie, Kirsty M.M. McConnell et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 23 citations · Full text

Life Sciences, Biochemistry, Pharmacology +6