Antidiabetic and toxicological evaluations of naringenin in normoglycaemic and NIDDM rat models and its implications on extra‐pancreatic glucose regulation

Rolffy Ortíz‐Andrade, Juan Carlos Sánchez‐Salgado, Gabriel Navarrete‐Vázquez, +7

Diabetes Obesity and Metabolism

Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis

Damian J. Mole, Scott P. Webster, Iain Uings, +24

Nature Medicine

InflammationAcute PancreatitisPancreatic CancerMedicineLiver Physiology +7

A comparative study of flavonoid analogues on streptozotocin–nicotinamide induced diabetic rats: Quercetin as a potential antidiabetic agent acting via 11β-Hydroxysteroid dehydrogenase type 1 inhibition

Mariana Torres‐Piedra, Rolffy Ortíz‐Andrade, Rafael Villalobos‐Molina, +6

European Journal of Medicinal Chemistry

BiochemistryMedicineDiabetesPharmacological AgentFlavonoid Analogues +4

Antidiabetic activity of N-(6-substituted-1,3-benzothiazol-2-yl)benzenesulfonamides

Hermenegilda Moreno‐Díaz, Rafael Villalobos‐Molina, Rolffy Ortíz‐Andrade, +8

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryMedicineNatural SciencesAntidiabetic Activity +4

Partial Deficiency or Short-Term Inhibition of 11β-Hydroxysteroid Dehydrogenase Type 1 Improves Cognitive Function in Aging Mice

Karen Sooy, Scott P. Webster, June Noble, +4

Journal of Neuroscience

AgingBrain FunctionBrain DevelopmentAging Mice11β-Hsd1 Activity +17

Cognitive and Disease-Modifying Effects of 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibition in Male Tg2576 Mice, a Model of Alzheimer's Disease

Karen Sooy, June Noble, Andrew McBride, +5

Endocrinology

Disease-modifying EffectsNeurochemical BiomarkersAlzheimer's DiseaseBrain HealthDegenerative Pathology +19

Kynurenine 3-monooxygenase is a critical regulator of renal ischemia–reperfusion injury

Xiaozhong Zheng, Ailiang Zhang, Margaret Binnie, +5

Experimental & Molecular Medicine

Discovery and biological evaluation of adamantyl amide 11β-HSD1 inhibitors

Scott P. Webster, Peter Ward, Margaret Binnie, +6

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinal Chemistry11β-Hsd1 InhibitorsMedicineNatural Sciences +6

Selection and early clinical evaluation of the brain‐penetrant 11β‐hydroxysteroid dehydrogenase type 1 (11β‐HSD1) inhibitor UE2343 (Xanamem™)

Scott P. Webster, Andrew McBride, Margaret Binnie, +10

British Journal of Pharmacology

Long-term cilostazol treatment reduces gliovascular damage and memory impairment in a mouse model of chronic cerebral hypoperfusion

Akihiro Kitamura, Yasmina Manso, Jessica Duncombe, +10

Scientific Reports