Iain Uings

Discovery and Characterization of Small Molecule Inhibitors of the BET Family Bromodomains

Chun‐wa Chung, Hervé Coste, Julia H. White et al. · Journal of Medicinal Chemistry · 2011 · 334 citations · Full text

Discovery of Epigenetic Regulator I-BET762: Lead Optimization to Afford a Clinical Candidate Inhibitor of the BET Bromodomains

Olivier Mirguet, Romain Gosmini, Jérôme Toum et al. · Journal of Medicinal Chemistry · 2013 · 301 citations · Full text

Histone Modifications, Chemoprevention Strategy, Epigenetic Change +22

Tyrosine phosphorylation is involved in receptor coupling to phospholipase D but not phospholipase C in the human neutrophil

Iain Uings, N. Thompson, Roger Randall et al. · Biochemical Journal · 1992 · 159 citations · Full text

Immunology, Receptor Coupling, Oxidative Stress +22

Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis

Damian J. Mole, Scott P. Webster, Iain Uings et al. · Nature Medicine · 2016 · 155 citations · Full text

Inflammation, Acute Pancreatitis, Pancreatic Cancer +9

Pharmacological properties of the enhanced-affinity glucocorticoid fluticasone furoate in vitro and in an in vivo model of respiratory inflammatory disease

Mark Salter, Keith Biggadike, Joyce Matthews et al. · American Journal of Physiology-Lung Cellular and Molecular Physiology · 2007 · 143 citations

Asthma, Inflammatory Lung Disease, Lung Inflammation +19