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Modulation of 11β-hydroxysteroid dehydrogenase type 1 activity by 1,5-substituted 1H-tetrazoles

Scott P. Webster, Margaret Binnie, Kirsty M.M. McConnell, Karen Sooy, Peter Ward, Michael F. Greaney, T. David Pallin, Hazel J. Dyke, Matthew Gill, I. Warner,

Bioorganic & Medicinal Chemistry Letters · 2010 · 23 citations · 17 references

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17

11β-Hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress

Yuri Kotelevtsev, Megan C. Holmes, Ann N. Burchell et al. · Proceedings of the National Academy of Sciences · 1997 · 855 citations

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Improved Lipid and Lipoprotein Profile, Hepatic Insulin Sensitivity, and Glucose Tolerance in 11β-Hydroxysteroid Dehydrogenase Type 1 Null Mice

Nicholas M. Morton, Megan C. Holmes, Catherine Fiévet et al. · Journal of Biological Chemistry · 2001 · 437 citations · Full text

, , +17

Molecular Field Extrema as Descriptors of Biological Activity:  Definition and Validation

Tim Cheeseright, Mark Mackey, Sally Rose et al. · Journal of Chemical Information and Modeling · 2006 · 401 citations

, , +17

11β-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice

Anne Hermanowski‐Vosatka, James M. Balkovec, Kang Cheng et al. · The Journal of Experimental Medicine · 2005 · 363 citations · Full text

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Lack of tissue glucocorticoid reactivation in 11β-hydroxysteroid dehydrogenase type 1 knockout mice ameliorates age-related learning impairments

Joyce L.W. Yau, June Noble, Christopher J. Kenyon et al. · Proceedings of the National Academy of Sciences · 2001 · 189 citations · Full text

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