Edna F. Choo

THE IMPACT OF P-GLYCOPROTEIN ON THE DISPOSITION OF DRUGS TARGETED FOR INDICATIONS OF THE CENTRAL NERVOUS SYSTEM: EVALUATION USING THE MDR1A/1B KNOCKOUT MOUSE MODEL

Angela C. Doran, R. Scott Obach, Bill J. Smith et al. · Drug Metabolism and Disposition · 2004 · 440 citations

Medicine, Pharmacokinetics, Pharmacology +16

Pharmacological Inhibition of P-glycoprotein Transport Enhances the Distribution of HIV-1 Protease Inhibitors into Brain and Testes

Edna F. Choo, Brenda F. Leake, Christoph Wandel et al. · Drug Metabolism and Disposition · 2000 · 394 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +17

A Novel Tankyrase Small-Molecule Inhibitor Suppresses <i>APC</i> Mutation–Driven Colorectal Tumor Growth

Ted Lau, Emily Chan, Marinella Callow et al. · Cancer Research · 2013 · 320 citations

Medicine, Oncology, Pharmacology +17

Antitumor Efficacy of the Novel RAF Inhibitor GDC-0879 Is Predicted by BRAFV600E Mutational Status and Sustained Extracellular Signal-Regulated Kinase/Mitogen-Activated Protein Kinase Pathway Suppression

Klaus P. Hoeflich, Sylvia Herter, Janet Tien et al. · Cancer Research · 2009 · 173 citations · Full text

Medicine, Oncology, Pharmacology +16

Therapeutic Targeting of the CBP/p300 Bromodomain Blocks the Growth of Castration-Resistant Prostate Cancer

Lingyan Jin, Jesse Garcia, Emily Chan et al. · Cancer Research · 2017 · 152 citations · Full text

Medicine, Molecular Biology, Oncology +17