Decreased insulin production and increased insulin sensitivity in the klotho mutant mouse, a novel animal model for human aging

Toshihiro Utsugi, Tomohisa Ohno, Yoshio Ohyama, +13

Metabolism

Metabolic SyndromeInsulin ProductionKlotho Mutant MouseAgingLongevity +11

Association analyses of the polymorphisms of angiotensin-converting enzyme and angiotensinogen genes with diabetic nephropathy in Japanese non-insulin-dependent diabetics

Tomio Ohno, Shoji Kawazu, Shoichi Tomono

Metabolism

Japanese Non-insulin-dependent DiabeticsMetabolic SyndromeHypertensionGenetic DeterminantMedicine +12

Age-Related Alteration of Pancreatic β-cell Function: Increased proinsulin and proinsulin-to-insulin molar ratio in elderly, but not in obese, subjects without glucose intolerance

Mitsuru Shimizu, S Kawazu, Shoichi Tomono, +6

Diabetes Care

HSF1 and constitutively active HSF1 improve vascular endothelial function (heat shock proteins improve vascular endothelial function)

Tsuyoshi Uchiyama, Hiroyuki Atsuta, Toshihiro Utsugi, +12

Atherosclerosis

InflammationAngiogenesisSignal TransductionSignaling PathwayVascular Endothelial Function +9

Genistein Augments Cyclic Adenosine 3′5′-Monophosphate (cAMP) Accumulation and Insulin Release in Min6 Cells

Tatsukuni Ohno, Naoya Kato, C. Ishii, +4

Endocrine Research

Hormone Replacement Therapy Decreases Insulin Resistance and Lipid Metabolism in Japanese Postmenopausal Women with Impaired and Normal Glucose Tolerance

Hiroyuki Sumino, Shûichi Ichikawa, Hiromaro Itoh, +9

Hormone Research in Paediatrics

Alamandine reduces leptin expression through the c-Src/p38 MAP kinase pathway in adipose tissue

Tsuyoshi Uchiyama, Fumikazu Okajima, Chihiro Mogi, +3

PLoS ONE

Simvastatin induces heat shock factor 1 in vascular endothelial cells

Tsuyoshi Uchiyama, Hiroyuki Atsuta, Toshihiro Utsugi, +11

Atherosclerosis

InflammationThrombosisVascular DiseaseAngiogenesisCardiovascular Disease +11

Oral implantation of Bacteroides asaccharolyticus and Eikenella corrodens in conventional hamsters

Tetsuji Nagahata, Tatsuo KIYOSHIGE, Shoichi Tomono, +3

Infection and Immunity

CaprineAntimicrobial SusceptibilityAntibioticsConventional HamstersOral Cavity +11

Clinical Significance of Neutrophil Apoptosis in Peripheral Blood of Patients with Type 2 Diabetes Mellitus

Chiaki Sudo, Hatsue Ogawara, A.W. Saleh, +8

Laboratory Hematology