Gabriel M. Belfort

High-performance genetically targetable optical neural silencing by light-driven proton pumps

Brian Y. Chow, Xue Han, Allison S. Dobry et al. · Nature · 2010 · 1.2K citations · Full text

Engineering, Bioengineering, Biotechnology +10

The Major Brain Cholesterol Metabolite 24(S)-Hydroxycholesterol Is a Potent Allosteric Modulator of<i>N</i>-Methyl-d-Aspartate Receptors

Steven M. Paul, James Doherty, Albert J. Robichaud et al. · Journal of Neuroscience · 2013 · 263 citations · Full text

Life Sciences, Neurobiology, Neuroscience +16

Preclinical characterization of zuranolone (SAGE-217), a selective neuroactive steroid GABAA receptor positive allosteric modulator

Alison L. Althaus, Michael A. Ackley, Gabriel M. Belfort et al. · Neuropharmacology · 2020 · 128 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14

Neuroactive Steroids. 2. 3α-Hydroxy-3β-methyl-21-(4-cyano-1 <i>H</i> -pyrazol-1′-yl)-19-nor-5β-pregnan-20-one (SAGE-217): A Clinical Next Generation Neuroactive Steroid Positive Allosteric Modulator of the (γ-Aminobutyric Acid) _A Receptor

Gabriel Martinez Botella, Francesco G. Salituro, Boyd L. Harrison et al. · Journal of Medicinal Chemistry · 2017 · 123 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +17

Neuroactive Steroids. 1. Positive Allosteric Modulators of the (γ-Aminobutyric Acid) _A Receptor: Structure–Activity Relationships of Heterocyclic Substitution at C-21

Gabriel Martinez Botella, Francesco G. Salituro, Boyd L. Harrison et al. · Journal of Medicinal Chemistry · 2015 · 55 citations

Life Sciences, Medicinal Chemistry, Pharmacology +17