Kang Zhao

Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases

Ying-Nan P. Chen, Matthew J. LaMarche, Ho Man Chan et al. · Nature · 2016 · 929 citations

Life Sciences, Cell Biology, Oncology +16

Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor

Jorge Fortanet, Christine Hiu-Tung Chen, Ying-Nan P. Chen et al. · Journal of Medicinal Chemistry · 2016 · 291 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +17

Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer

Matthew J. LaMarche, Michael Acker, Andreea Argintaru et al. · Journal of Medicinal Chemistry · 2020 · 222 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

TMEM41B is a novel regulator of autophagy and lipid mobilization

Francesca Moretti, Phil Bergman, Stacie E. Dodgson et al. · EMBO Reports · 2018 · 178 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +11

Adenoviral gene transfer of <i>Caenorhabditis elegans n</i> −3 fatty acid desaturase optimizes fatty acid composition in mammalian cells

Kang Zhao, Yinlin Ge, Zhihong Chen et al. · Proceedings of the National Academy of Sciences · 2001 · 104 citations · Full text

Life Sciences, Biochemistry, Physiology +17