Scott Throner

Discovery of AZD9833, a Potent and Orally Bioavailable Selective Estrogen Receptor Degrader and Antagonist

James S. Scott, Amber Balazs, Bernard Barlaam et al. · Journal of Medicinal Chemistry · 2020 · 111 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering

Jeffrey W. Johannes, Lynsie Almeida, Kevin Daly et al. · Bioorganic & Medicinal Chemistry Letters · 2015 · 63 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +6

Discovery of (2<i>R</i>)-<i>N</i>-[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]-1<i>H</i>-indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a Potent and Selective Janus Kinase 1 Inhibitor

Qibin Su, Erica Banks, Geraldine Bebernitz et al. · Journal of Medicinal Chemistry · 2020 · 60 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +15

Design, Synthesis, and Biological Activity of Substrate Competitive SMYD2 Inhibitors

Scott D. Cowen, Daniel Russell, Leslie Dakin et al. · Journal of Medicinal Chemistry · 2016 · 36 citations · Full text

Life Sciences, Molecular Biology, Oncology +17

Discovery of novel positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5)

Jeffrey Varnes, Andrew P. Marcus, Russell C. Mauger et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 34 citations · Full text

Medicine, Neuroscience, Pharmacology +14