Concepedia

Leslie Dakin

LD

6

Publications

444

Citations

6

H-Index

2016

Active since

Affiliations

Pfizer (United States)(Current)

WuXi AppTec (China)

Leslie Dakin is an author at Pfizer (United States) specializing in medicinal chemistry, drug discovery, and biochemistry.

Top concepts

Publications per year

2016–2025

6

Publications

6

Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay

J. Perry Hall, Amy Brault, Fabien Vincent et al. · PLoS ONE · 2017 · 157 citations · Full text

Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637)

Alexander M. Taylor, Alexandre Côté, Michael C. Hewitt et al. · ACS Medicinal Chemistry Letters · 2016 · 111 citations · Full text

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The catalytic mechanism of cyclic GMP‐AMP synthase (cGAS) and implications for innate immunity and inhibition

J. Perry Hall, Erik C. Ralph, Suman Shanker et al. · Protein Science · 2017 · 64 citations · Full text

Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists

Shenping Liu, Leslie Dakin, Xing Li et al. · Scientific Reports · 2016 · 60 citations · Full text

Design, Synthesis, and Biological Activity of Substrate Competitive SMYD2 Inhibitors

Scott D. Cowen, Daniel Russell, Leslie Dakin et al. · Journal of Medicinal Chemistry · 2016 · 36 citations · Full text

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