Henriëtte M. G. Willems

Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein–Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery

Thomas G. Davies, William E. Wixted, Joseph E. Coyle et al. · Journal of Medicinal Chemistry · 2016 · 295 citations · Full text

Molecular Biology, Chemical Biology, Redox Biology +19

Small-Molecule Inhibitors of the MDM2-p53 Protein−Protein Interaction Based on an Isoindolinone Scaffold

Ian R. Hardcastle, Shafiq U. Ahmed, Helen Atkins et al. · Journal of Medicinal Chemistry · 2006 · 144 citations · Full text

Mdm2-p53 Interaction, Drug Target, Isoindolinone Scaffold +17

Isoindolinone-based inhibitors of the MDM2–p53 protein–protein interaction

Ian R. Hardcastle, Shafiq U. Ahmed, Helen Atkins et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 91 citations

Molecular Pharmacology, Biochemistry, Isoindolinone-based Inhibitors +7

Structure–Activity and Structure–Conformation Relationships of Aryl Propionic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1/Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1/NRF2) Protein–Protein Interaction

Tom D. Heightman, James F. Callahan, Elisabetta Chiarparin et al. · Journal of Medicinal Chemistry · 2019 · 91 citations · Full text

Systematic Investigation of the Permeability of Androgen Receptor PROTACs

Duncan E. Scott, Timothy P. C. Rooney, Elliott D. Bayle et al. · ACS Medicinal Chemistry Letters · 2020 · 67 citations · Full text

Androgen Receptor, Protein Assembly, Molecular Biology +16