Darlene Romashko

A mouse model of Rubinstein-Taybi syndrome: Defective long-term memory is ameliorated by inhibitors of phosphodiesterase 4

Rusiko Bourtchouladze, Regina Lidge, Ray Catapano et al. · Proceedings of the National Academy of Sciences · 2003 · 314 citations · Full text

Life Sciences, Molecular Biology, Pharmacology +14

Discovery of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1: Optimization of kinase selectivity and pharmacokinetics

Keith R. Hornberger, Xin Chen, Andrew P. Crew et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 26 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12

Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1

Keith R. Hornberger, Dan M. Berger, Andrew P. Crew et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 21 citations · Full text

Pharmacy, Chemistry, Medicinal Chemistry +10

Reversible Linkage of Two Distinct Small Molecule Inhibitors of Myc Generates a Dimeric Inhibitor with Improved Potency That Is Active in Myc Over-Expressing Cancer Cell Lines

Jutta Wanner, Darlene Romashko, Douglas S. Werner et al. · PLoS ONE · 2015 · 18 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +16

Computational and Functional Analyses of HER2 Mutations Reveal Allosteric Activation Mechanisms and Altered Pharmacologic Effects

Noboru Ishiyama, Matthew O’Connor, Andrei Salomatov et al. · Cancer Research · 2022 · 17 citations · Full text

Medicine, Oncology, Pharmacology +13