Douglas S. Werner

Different apoptotic mechanisms are involved in the antiproliferative effects of 7β-hydroxysitosterol and 7β-hydroxycholesterol in human colon cancer cells

Stamatiki Roussi, Anja Winter, Francine Gossé et al. · Cell Death and Differentiation · 2004 · 71 citations · Full text

Life Sciences, Biochemistry, Oncology +10

Novel, Self-Assembling Dimeric Inhibitors of Human β Tryptase

Sarah F. Giardina, Douglas S. Werner, Maneesh Pingle et al. · Journal of Medicinal Chemistry · 2020 · 40 citations

Pharmacy, Medicinal Chemistry, Pharmacology +16

Imidazo[1,5-a]pyrazines: Orally efficacious inhibitors of mTORC1 and mTORC2

Andrew P. Crew, Shripad V. Bhagwat, Hanqing Dong et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 23 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +8

Reversible Linkage of Two Distinct Small Molecule Inhibitors of Myc Generates a Dimeric Inhibitor with Improved Potency That Is Active in Myc Over-Expressing Cancer Cell Lines

Jutta Wanner, Darlene Romashko, Douglas S. Werner et al. · PLoS ONE · 2015 · 18 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +16

Is Protein Kinase Substrate Efficacy a Reliable Barometer for Successful Inhibitor Design?

Douglas S. Werner, Tae Ryong Lee, David S. Lawrence · Journal of Biological Chemistry · 1996 · 13 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16