Matthew O’Connor

Discovery of OSI-906: A Selective and Orally Efficacious Dual Inhibitor of the IGF-1 Receptor and Insulin Receptor

Mark J. Mulvihill, Andrew Cooke, Maryland Rosenfeld-Franklin et al. · Future Medicinal Chemistry · 2009 · 307 citations · Full text

A novel, potent, and selective insulin-like growth factor-I receptor kinase inhibitor blocks insulin-like growth factor-I receptor signaling <i>in vitro</i> and inhibits insulin-like growth factor-I receptor–dependent tumor growth <i>in vivo</i>

Qunsheng Ji, Mark J. Mulvihill, Maryland Rosenfeld-Franklin et al. · Molecular Cancer Therapeutics · 2007 · 147 citations · Full text

Igf-ii Expression, Signal Transduction, Growth Hormone +14

OSI-930: A Novel Selective Inhibitor of Kit and Kinase Insert Domain Receptor Tyrosine Kinases with Antitumor Activity in Mouse Xenograft Models

Andrew J. Garton, Andrew P. Crew, Maryland Franklin et al. · Cancer Research · 2006 · 80 citations · Full text

Mouse Xenograft Models, Antitumor Activity, Chemoprevention Strategy +18

Optimizing Cerebral Autoregulation May Decrease Neonatal Regional Hypoxic-Ischemic Brain Injury

Jennifer K. Lee, Andrea Poretti, Jamie Perin et al. · Developmental Neuroscience · 2016 · 75 citations · Full text

Inducible expression of TGFβ, Snail and Zeb1 recapitulates EMT in vitro and in vivo in a NSCLC model

Gretchen Argast, Joseph S. Krueger, Stuart Thomson et al. · Clinical & Experimental Metastasis · 2011 · 58 citations

Nsclc Model, Developmental Biology, Signal Transduction +9