Keith R. Hornberger

Discovery of Dabrafenib: A Selective Inhibitor of Raf Kinases with Antitumor Activity against B-Raf-Driven Tumors

Tara Rheault, John Stellwagen, George M. Adjabeng et al. · ACS Medicinal Chemistry Letters · 2013 · 253 citations · Full text

B-raf-driven Tumors, Antitumor Activity, Hyperactive Signaling +16

Total Synthesis of Leucascandrolide A

Keith R. Hornberger, Christopher L. Hamblett, James L. Leighton · Journal of the American Chemical Society · 2000 · 185 citations

Molecular Sciences, Bioorganic Chemistry, Engineering +14

Physicochemical Property Determinants of Oral Absorption for PROTAC Protein Degraders

Keith R. Hornberger, Erika Araujo · Journal of Medicinal Chemistry · 2023 · 121 citations · Full text

Protac Protein Degraders, Protein Refolding, Food Chemistry +20

Evidence for Allosteric Interactions of Antagonist Binding to the Smoothened Receptor

Cynthia M. Rominger, Weilin Tiger Bee, Robert A. Copeland et al. · Journal of Pharmacology and Experimental Therapeutics · 2009 · 63 citations

Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding

Kyle A. Emmitte, George M. Adjebang, C. Webb Andrews et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 61 citations · Full text

Biochemistry, Medicine, Natural Sciences +9