Christopher J. Farady

<scp>GSDMD</scp> membrane pore formation constitutes the mechanism of pyroptotic cell death

Lorenzo Sborgi, Sebastian Rühl, Estefania Mulvihill et al. · The EMBO Journal · 2016 · 1.1K citations · Full text

Extrinsic and intrinsic apoptosis activate pannexin‐1 to drive <scp>NLRP</scp> 3 inflammasome assembly

Kaiwen Chen, Benjamin Demarco, Rosalie Heilig et al. · The EMBO Journal · 2019 · 375 citations · Full text

Inflammation, Signal Transduction, Signaling Pathway +12

Vinyl Sulfones as Antiparasitic Agents and a Structural Basis for Drug Design

Iain D. Kerr, Ji Hae Lee, Christopher J. Farady et al. · Journal of Biological Chemistry · 2009 · 291 citations · Full text

ADAM17 is the main sheddase for the generation of human triggering receptor expressed in myeloid cells (hTREM2) ectodomain and cleaves TREM2 after Histidine 157

Dominik Feuerbach, Patrick Schindler, Carmen Barske et al. · Neuroscience Letters · 2017 · 179 citations

Histidine 157, Cleaves Trem2, G Protein-coupled Receptor +7

Crystal Structure of NLRP3 NACHT Domain With an Inhibitor Defines Mechanism of Inflammasome Inhibition

Carien Dekker, Henri Mattes, Michael Wright et al. · Journal of Molecular Biology · 2021 · 149 citations

Crystal Structure, Anti-inflammatory, Signal Transduction +9