Joseph Cacciola

Discovery of 1-[3-(Aminomethyl)phenyl]-<i>N</i>-[3-fluoro-2‘-(methylsulfonyl)- [1,1‘-biphenyl]-4-yl]-3-(trifluoromethyl)-1<i>H</i>-pyrazole-5-carboxamide (DPC423), a Highly Potent, Selective, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa

Donald Pinto, Michael J. Orwat, Shuaige Wang et al. · Journal of Medicinal Chemistry · 2001 · 172 citations · Full text

Medicine, Pharmacology, Drug Discovery +11

Preparation of 1-(4-methoxyphenyl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-ones as potent, selective and bioavailable inhibitors of coagulation factor Xa

John M. Fevig, Joseph Cacciola, Joseph Buriak et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 54 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +9

Rational design of boropeptide thrombin inhibitors: β,β-dialkyl-phenethylglycine P2 analogs of DuP 714 with greater selectivity over complement factor I and an improved safety profile

John M. Fevig, Joseph Buriak, Joseph Cacciola et al. · Bioorganic & Medicinal Chemistry Letters · 1998 · 45 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Preparation of 1-(3-aminobenzo[d]isoxazol-5-yl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-ones as potent, selective, and efficacious inhibitors of coagulation factor Xa

Yunlong Li, John M. Fevig, Joseph Cacciola et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 31 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +10

Discovery of Spirofused Piperazine and Diazepane Amides as Selective Histamine-3 Antagonists with in Vivo Efficacy in a Mouse Model of Cognition

Dean G. Brown, Peter R Bernstein, Andrew M. Griffin et al. · Journal of Medicinal Chemistry · 2014 · 27 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +15