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Rational design of boropeptide thrombin inhibitors: β,β-dialkyl-phenethylglycine P2 analogs of DuP 714 with greater selectivity over complement factor I and an improved safety profile

Medicinal ChemistryBiochemistryRational DesignMedicineNatural SciencesRational Drug DesignPeptide TherapeuticPharmacotherapyNon-peptide LigandDup 714PharmacologyMolecular ModelingComplement FactorDrug Discovery