Andrew Capen

The CDK4/6 Inhibitor Abemaciclib Induces a T Cell Inflamed Tumor Microenvironment and Enhances the Efficacy of PD-L1 Checkpoint Blockade

David Schaer, Richard P. Beckmann, Jack Dempsey et al. · Cell Reports · 2018 · 460 citations · Full text

Medicine, Immunology, Pharmacology +17

The Protein Kinase Cβ–Selective Inhibitor, Enzastaurin (LY317615.HCl), Suppresses Signaling through the AKT Pathway, Induces Apoptosis, and Suppresses Growth of Human Colon Cancer and Glioblastoma Xenografts

Jeremy R. Graff, Ann M. McNulty, Kimberly R. Hanna et al. · Cancer Research · 2005 · 437 citations · Full text

Medicine, Oncology, Pharmacology +15

Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicity

Jeremy R. Graff, Bruce W. Konicek, Thomas M. Vincent et al. · Journal of Clinical Investigation · 2007 · 379 citations · Full text

Medicine, Cancer Biology, Oncology +17

The Folate Pathway Inhibitor Pemetrexed Pleiotropically Enhances Effects of Cancer Immunotherapy

David Schaer, Sandaruwan Geeganage, Nelusha Amaladas et al. · Clinical Cancer Research · 2019 · 127 citations

Life Sciences, Immunology, Oncology +17

Activating the Wnt/β-Catenin Pathway for the Treatment of Melanoma – Application of LY2090314, a Novel Selective Inhibitor of Glycogen Synthase Kinase-3

Jennifer M. Atkinson, Kenneth B. Rank, Yi Arial Zeng et al. · PLoS ONE · 2015 · 107 citations · Full text

Medicine, Oncology, Pharmacology +17