The Protein Kinase Cβ–Selective Inhibitor, Enzastaurin (LY317615.HCl), Suppresses Signaling through the AKT Pathway, Induces Apoptosis, and Suppresses Growth of Human Colon Cancer and Glioblastoma Xenografts

Jeremy R. Graff, Ann M. McNulty, Kimberly R. Hanna, +16

Cancer Research

Increased AKT Activity Contributes to Prostate Cancer Progression by Dramatically Accelerating Prostate Tumor Growth and Diminishing p27Kip1 Expression

Jeremy R. Graff, Bruce W. Konicek, Ann M. McNulty, +9

Journal of Biological Chemistry

Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicity

Jeremy R. Graff, Bruce W. Konicek, Thomas M. Vincent, +24

Journal of Clinical Investigation

Tumor BiologyTherapeutic SuppressionMedicineTumor GrowthEif4e Mrna +10

eIF4E Activation Is Commonly Elevated in Advanced Human Prostate Cancers and Significantly Related to Reduced Patient Survival

Jeremy R. Graff, Bruce W. Konicek, Rebecca L. Lynch, +14

Cancer Research

Eif4e ActivationUrologyGenitourinary CancerReduced Patient SurvivalMedicine +9

Preclinical characterization of abemaciclib in hormone receptor positive breast cancer

Raquel Torres-Guzmán, Bruna Calsina, Ana Hermoso, +11

Oncotarget

Therapeutic Inhibition of MAP Kinase Interacting Kinase Blocks Eukaryotic Initiation Factor 4E Phosphorylation and Suppresses Outgrowth of Experimental Lung Metastases

Bruce W. Konicek, Jennifer R. Stephens, Ann M. McNulty, +14

Cancer Research

Bioavailable Mnk InhibitorCancer BiologyTumor BiologySignaling PathwayCell Regulation +19

Design and synthesis of novel monocyclic β-lactam inhibitors of prostate specific antigen

Robert M. Adlington, Jack E. Baldwin, Beining Chen, +8

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryPharmaceutical ScienceBiochemistryMedicineNatural Sciences +8

Design, Synthesis, and Proposed Active Site Binding Analysis of Monocyclic 2-Azetidinone Inhibitors of Prostate Specific Antigen

Robert M. Adlington, Jack E. Baldwin, Gerald W. Becker, +9

Journal of Medicinal Chemistry

Gastrocystoplasty and Colocystoplasty in Canines: The Metabolic Consequences of Acute Saline and Acid Loading

Joel A. Piser, Michael E. Mitchell, Thomas B. Kulb, +3

The Journal of Urology

GastroenterologyAugmentation CystoplastySurgeryDigestive TractElectrolyte Disturbance +15

The Progression of LNCaP Human Prostate Cancer Cells to Androgen Independence Involves Decreased FOXO3a Expression and Reduced <i>p27KIP1</i> Promoter Transactivation

Rebecca L. Lynch, Bruce W. Konicek, Ann M. McNulty, +4

Molecular Cancer Research

Cancer BiologyFoxo3a ExpressionTumor BiologyHuman Prostate CancerTranscriptional Regulation +16