Terry Macintyre

Discovery of a Novel Class of Dimeric Smac Mimetics as Potent IAP Antagonists Resulting in a Clinical Candidate for the Treatment of Cancer (AZD5582)

Edward J. Hennessy, Ammar Adam, Brian Aquila et al. · Journal of Medicinal Chemistry · 2013 · 112 citations · Full text

Compound 14, Apoptosis, Cell Death +18

Identification of 4-Aminopyrazolylpyrimidines as Potent Inhibitors of Trk Kinases

Tao Wang, Michelle L. Lamb, David A. Scott et al. · Journal of Medicinal Chemistry · 2008 · 74 citations · Full text

Trk Kinases, Medicinal Chemistry, Pharmaceutical Science +15

AZD4320, A Dual Inhibitor of Bcl-2 and Bcl-xL, Induces Tumor Regression in Hematologic Cancer Models without Dose-limiting Thrombocytopenia

Srividya B. Balachander, Steven W. Criscione, Kate F. Byth et al. · Clinical Cancer Research · 2020 · 64 citations

Identification and preclinical characterization of AZ-23, a novel, selective, and orally bioavailable inhibitor of the Trk kinase pathway

Kenneth S. Thress, Terry Macintyre, Haiyun Wang et al. · Molecular Cancer Therapeutics · 2009 · 58 citations

Discovery of Disubstituted Imidazo[4,5-<i>b</i>]pyridines and Purines as Potent TrkA Inhibitors

Tao Wang, Michelle L. Lamb, M. Block et al. · ACS Medicinal Chemistry Letters · 2012 · 45 citations · Full text

Potent Trka Inhibitors, Medicinal Chemistry, Crystal Structure +15