David A. Scott

An open-source drug discovery platform enables ultra-large virtual screens

Christoph Gorgulla, Andras Boeszoermenyi, Zifu Wang et al. · Nature · 2020 · 612 citations · Full text

Virtual Screening, Hit Identification, Medicine +5

Exploring Targeted Degradation Strategy for Oncogenic KRASG12C

Mei Zeng, Yuan Xiong, Nozhat Safaee et al. · Cell chemical biology · 2019 · 266 citations · Full text

Oncogenic Agent, Molecular Biology, Degradation Reaction +3

An allosteric inhibitor against the therapy-resistant mutant forms of EGFR in non-small cell lung cancer

Ciric To, Tyler S. Beyett, Jaebong Jang et al. · Nature Cancer · 2022 · 146 citations · Full text

Therapy-resistant Mutant Forms, Medicine, Pharmacology +9

Potent and Selective Covalent Quinazoline Inhibitors of KRAS G12C

Mei Zeng, Jia Lu, Lianbo Li et al. · Cell chemical biology · 2017 · 134 citations · Full text

Medicinal Chemistry, Kras G12c, Medicine +6

Development and Characterization of a Wee1 Kinase Degrader

Zhengnian Li, Benika J. Pinch, Katherine A. Donovan et al. · Cell chemical biology · 2019 · 99 citations · Full text

Cell Division, Receptor Tyrosine Kinase, Protein Degradation +6