Initiation of Apoptosis by Granzyme B Requires Direct Cleavage of Bid, but Not Direct Granzyme B–Mediated Caspase Activation

Vivien R. Sutton, Joanne E. Davis, Michael Cancilla, +5

The Journal of Experimental Medicine

Novel mechanisms of apoptosis induced by histone deacetylase inhibitors.

Melissa J. Peart, Kellie M. Tainton, Astrid A. Ruefli, +6

PubMed

Histone ModificationsMitophagyChemoprevention StrategyApoptosisCell Death +14

A Central Role for Bid in Granzyme B-induced Apoptosis

Nigel J. Waterhouse, Karin Sedelies, Kylie A. Browne, +9

Journal of Biological Chemistry

MitophagyCentral RoleMitochondrial FunctionGranzyme B-induced ApoptosisApoptosis +12

hScrib is a functional homologue of the Drosophila tumour suppressor Scribble

Lukas E. Dow, Anthony M. Brumby, Rosa Muratore, +6

Oncogene

ChromatinDrosophila Tumour SuppressorFunctional HomologueGene RegulationMolecular Genetics +5

Discordant Regulation of Granzyme H and Granzyme B Expression in Human Lymphocytes

Karin Sedelies, Thomas J. Sayers, Kirsten M. Edwards, +4

Journal of Biological Chemistry

Cytotoxic T lymphocyte–induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis

Nigel J. Waterhouse, Vivien R. Sutton, Karin Sedelies, +5

The Journal of Cell Biology

Residual active granzyme B in cathepsin C–null lymphocytes is sufficient for perforin-dependent target cell apoptosis

Vivien R. Sutton, Nigel J. Waterhouse, Kylie A. Browne, +6

The Journal of Cell Biology

Mouse granzyme A induces a novel death with writhing morphology that is mechanistically distinct from granzyme B-induced apoptosis

Olivia Susanto, Sarah E. Stewart, Ilia Voskoboinik, +8

Cell Death and Differentiation

Knockout MouseMitophagyGranzyme B-induced ApoptosisApoptosisImmunology +7

Functional dissociation of ΔΨm and cytochrome c release defines the contribution of mitochondria upstream of caspase activation during granzyme B-induced apoptosis

Nigel J. Waterhouse, Karin Sedelies, Vivien R. Sutton, +6

Cell Death and Differentiation

Signal TransductionBiochemistryMitochondrial FunctionMedicineFunctional Dissociation +11

The granzyme B-Serpinb9 axis controls the fate of lymphocytes after lysosomal stress

Catherina H. Bird, Melinda E. Christensen, Matthew Mangan, +6

Cell Death and Differentiation

Autoimmune DiseaseCell DivisionLymphocyte DevelopmentGranulocyteGenetics +9