Astrid A. Ruefli

The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species

Astrid A. Ruefli, Michael J. Ausserlechner, David Bernhard et al. · Proceedings of the National Academy of Sciences · 2001 · 489 citations · Full text

Life Sciences, Cell Biology, Pharmacology +17

Initiation of Apoptosis by Granzyme B Requires Direct Cleavage of Bid, but Not Direct Granzyme B–Mediated Caspase Activation

Vivien R. Sutton, Joanne E. Davis, Michael Cancilla et al. · The Journal of Experimental Medicine · 2000 · 366 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +15

Novel mechanisms of apoptosis induced by histone deacetylase inhibitors.

Melissa J. Peart, Kellie M. Tainton, Astrid A. Ruefli et al. · PubMed · 2003 · 232 citations

Life Sciences, Oncology, Pharmacology +17

Calcium regulates processing of the Alzheimer amyloid protein precursor in a protein kinase C-independent manner.

Joseph D. Buxbaum, Astrid A. Ruefli, Christine A. Parker et al. · Proceedings of the National Academy of Sciences · 1994 · 183 citations · Full text

Life Sciences, Biochemistry, Neuroscience +16

Histone deacetylase inhibitors specifically kill nonproliferating tumour cells

Andrew Burgess, Astrid A. Ruefli, Heather Beamish et al. · Oncogene · 2004 · 128 citations

Medicine, Cancer Biology, Oncology +14