Christiane Boezio

Sulfonamides as Selective Na_V1.7 Inhibitors: Optimizing Potency, Pharmacokinetics, and Metabolic Properties to Obtain Atropisomeric Quinolinone (AM-0466) that Affords Robust in Vivo Activity

Russell F. Graceffa, Alessandro A. Boezio, Jessica Able et al. · Journal of Medicinal Chemistry · 2017 · 69 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Discovery and optimization of potent and selective imidazopyridine and imidazopyridazine mTOR inhibitors

Emily A. Peterson, Alessandro A. Boezio, Paul S. Andrews et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 36 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Discovery of (<i>R</i>)-6-(1-(8-Fluoro-6-(1-methyl-1<i>H</i>-pyrazol-4-yl)-[1,2,4]triazolo[4,3-<i>a</i>]pyridin-3-yl)ethyl)-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6<i>H</i>)-one (AMG 337), a Potent and Selective Inhibitor of MET with High Unbound Target Coverage and Robust In Vivo Antitumor Activity

Alessandro A. Boezio, Katrina W. Copeland, Karen Rex et al. · Journal of Medicinal Chemistry · 2016 · 35 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13

Discovery of Potent and Selective 8-Fluorotriazolopyridine c-Met Inhibitors

Emily A. Peterson, Yohannes Teffera, Brian K. Albrecht et al. · Journal of Medicinal Chemistry · 2015 · 33 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14

1,2,4-Triazolsulfone: A novel isosteric replacement of acylsulfonamides in the context of NaV1.7 inhibition

Alessandro A. Boezio, Kristin L. Andrews, Christiane Boezio et al. · Bioorganic & Medicinal Chemistry Letters · 2018 · 11 citations · Full text

Pharmacy, Chemistry, Medicinal Chemistry +10