Julius Apuy

Optimization of a Series of Triazole Containing Mammalian Target of Rapamycin (mTOR) Kinase Inhibitors and the Discovery of CC-115

Deborah S. Mortensen, Sophie Perrin-Ninkovic, Graziella Shevlin et al. · Journal of Medicinal Chemistry · 2015 · 73 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Ratiometric Pulsed Alkylation/Mass Spectrometry of the Cysteine Pairs in Individual Zinc Fingers of MRE-Binding Transcription Factor-1 (MTF-1) as a Probe of Zinc Chelate Stability

Julius Apuy, Xiaohua Chen, David H. Russell et al. · Biochemistry · 2001 · 58 citations

Life Sciences, Biochemistry, Molecular Biology +16

Identification of 1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea Hydrochloride (CEP-32496), a Highly Potent and Orally Efficacious Inhibitor of V-RAF Murine Sarcoma Viral Oncogene Homologue B1 (BRAF) V600E

Martin W. Rowbottom, Raffaella Faraoni, Qi Chao et al. · Journal of Medicinal Chemistry · 2011 · 58 citations · Full text

Medicine, Oncology, Pharmacology +14

Characterization of a metalloregulatory bismuth(III) site in Staphylococcus aureus pI258 CadC repressor

Laura S. Busenlehner, Julius Apuy, David Giedroc · JBIC Journal of Biological Inorganic Chemistry · 2002 · 53 citations

Natural Sciences, Chemistry, Microbiology +7

CC-223, a Potent and Selective Inhibitor of mTOR Kinase: <i>In Vitro</i> and <i>In Vivo</i> Characterization

Deborah S. Mortensen, Kimberly E. Fultz, Shuichan Xu et al. · Molecular Cancer Therapeutics · 2015 · 53 citations · Full text

Medicine, Oncology, Pharmacology +14