Graziella Shevlin

Inhibitors of NF-κB and AP-1 Gene Expression:  SAR Studies on the Pyrimidine Portion of 2-Chloro-4-trifluoromethylpyrimidine-5-[<i>N</i>-(3‘,5‘-bis(trifluoromethyl)phenyl)carboxamide]

Moorthy S. S. Palanki, Paul Erdman, Leah M. Gayo‐Fung et al. · Journal of Medicinal Chemistry · 2000 · 80 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

Optimization of a Series of Triazole Containing Mammalian Target of Rapamycin (mTOR) Kinase Inhibitors and the Discovery of CC-115

Deborah S. Mortensen, Sophie Perrin-Ninkovic, Graziella Shevlin et al. · Journal of Medicinal Chemistry · 2015 · 73 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Structure–Activity Relationship Studies of Ethyl 2-[(3-Methyl-2,5-dioxo(3-pyrrolinyl))amino]-4-(trifluoromethyl)pyrimidine-5-carboxylate: An Inhibitor of AP-1 and NF-κB Mediated Gene Expression

Moorthy S. S. Palanki, Leah M. Gayo‐Fung, Graziella Shevlin et al. · Bioorganic & Medicinal Chemistry Letters · 2002 · 45 citations

Pharmacy, Medicinal Chemistry, Pharmacology +10

Lead identification of a potent benzopyranone selective estrogen receptor modulator

Jeffrey A. McKie, Shripad S. Bhagwat, Helen Brady et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 38 citations

Pharmacy, Medicinal Chemistry, Pharmacology +12

Discovery and SAR exploration of a novel series of imidazo[4,5-b]pyrazin-2-ones as potent and selective mTOR kinase inhibitors

Deborah S. Mortensen, Sophie Perrin-Ninkovic, Roy Harris et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 33 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13