Paul Erdman

Small Molecules Co-targeting CKIα and the Transcriptional Kinases CDK7/9 Control AML in Preclinical Models

Waleed Minzel, Avanthika Venkatachalam, Avner Fink et al. · Cell · 2018 · 148 citations · Full text

Transcriptional Regulation, Signal Transduction, Signaling Pathway +10

Discovery of Antibacterial Biotin Carboxylase Inhibitors by Virtual Screening and Fragment-Based Approaches

Igor Mochalkin, J. Richard Miller, Lakshmi Narasimhan et al. · ACS Chemical Biology · 2009 · 104 citations · Full text

Drug Target, Bioorganic Chemistry, Hit Identification +21

Inhibitors of NF-κB and AP-1 Gene Expression:  SAR Studies on the Pyrimidine Portion of 2-Chloro-4-trifluoromethylpyrimidine-5-[<i>N</i>-(3‘,5‘-bis(trifluoromethyl)phenyl)carboxamide]

Moorthy S. S. Palanki, Paul Erdman, Leah M. Gayo‐Fung et al. · Journal of Medicinal Chemistry · 2000 · 80 citations · Full text

Pharmaceutical Science, Caco-2 Permeability, Pharmacotherapy +16

The Discovery of a Dual TTK Protein Kinase/CDC2-Like Kinase (CLK2) Inhibitor for the Treatment of Triple Negative Breast Cancer Initiated from a Phenotypic Screen

Jennifer R. Riggs, Mark A. Nagy, Jan Elsner et al. · Journal of Medicinal Chemistry · 2017 · 59 citations · Full text

Breast Oncology, Pharmaceutical Chemistry, Tumor Biology +18

Structure–Activity Relationship Studies of Ethyl 2-[(3-Methyl-2,5-dioxo(3-pyrrolinyl))amino]-4-(trifluoromethyl)pyrimidine-5-carboxylate: An Inhibitor of AP-1 and NF-κB Mediated Gene Expression

Moorthy S. S. Palanki, Leah M. Gayo‐Fung, Graziella Shevlin et al. · Bioorganic & Medicinal Chemistry Letters · 2002 · 45 citations

Molecular Pharmacology, Biochemistry, Medicine +7