Roy Harris

Optimization of a Series of Triazole Containing Mammalian Target of Rapamycin (mTOR) Kinase Inhibitors and the Discovery of CC-115

Deborah S. Mortensen, Sophie Perrin-Ninkovic, Graziella Shevlin et al. · Journal of Medicinal Chemistry · 2015 · 72 citations · Full text

Drug Target, Kinase Inhibitors, Pharmacotherapy +16

The Discovery of a Dual TTK Protein Kinase/CDC2-Like Kinase (CLK2) Inhibitor for the Treatment of Triple Negative Breast Cancer Initiated from a Phenotypic Screen

Jennifer R. Riggs, Mark A. Nagy, Jan Elsner et al. · Journal of Medicinal Chemistry · 2017 · 59 citations · Full text

Breast Oncology, Pharmaceutical Chemistry, Tumor Biology +18

Discovery and SAR exploration of a novel series of imidazo[4,5-b]pyrazin-2-ones as potent and selective mTOR kinase inhibitors

Deborah S. Mortensen, Sophie Perrin-Ninkovic, Roy Harris et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 32 citations · Full text

Sar Exploration, Medicinal Chemistry, Drug Target +11

Discovery of Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor CC-223

Deborah S. Mortensen, Sophie Perrin-Ninkovic, Graziella Shevlin et al. · Journal of Medicinal Chemistry · 2015 · 32 citations · Full text

Drug Target, Kinase Inhibitors, Pharmacotherapy +22

Use of core modification in the discovery of CC214-2, an orally available, selective inhibitor of mTOR kinase

Deborah S. Mortensen, John Sapienza, Branden G.S. Lee et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 27 citations · Full text

Signal Transduction, Signaling Pathway, Molecular Pathway +10