Branden G.S. Lee

Optimization of a Series of Triazole Containing Mammalian Target of Rapamycin (mTOR) Kinase Inhibitors and the Discovery of CC-115

Deborah S. Mortensen, Sophie Perrin-Ninkovic, Graziella Shevlin et al. · Journal of Medicinal Chemistry · 2015 · 73 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Discovery and SAR exploration of a novel series of imidazo[4,5-b]pyrazin-2-ones as potent and selective mTOR kinase inhibitors

Deborah S. Mortensen, Sophie Perrin-Ninkovic, Roy Harris et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 33 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

Discovery of Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor CC-223

Deborah S. Mortensen, Sophie Perrin-Ninkovic, Graziella Shevlin et al. · Journal of Medicinal Chemistry · 2015 · 33 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Use of core modification in the discovery of CC214-2, an orally available, selective inhibitor of mTOR kinase

Deborah S. Mortensen, John Sapienza, Branden G.S. Lee et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 27 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12