Lauren R. Polstein

RNA-guided gene activation by CRISPR-Cas9–based transcription factors

Pablo Pérez‐Piñera, D. Dewran Koçak, Christopher M. Vockley et al. · Nature Methods · 2013 · 1.3K citations · Full text

Transcriptional Regulation, Natural Sciences, Molecular Biology +6

A light-inducible CRISPR-Cas9 system for control of endogenous gene activation

Lauren R. Polstein, Charles A. Gersbach · Nature Chemical Biology · 2015 · 639 citations · Full text

Light-inducible Crispr-cas9 System, Off-target Effect, Natural Sciences +8

Light-Inducible Spatiotemporal Control of Gene Activation by Customizable Zinc Finger Transcription Factors

Lauren R. Polstein, Charles A. Gersbach · Journal of the American Chemical Society · 2012 · 193 citations · Full text

Engineering, Genetics, Zinc Finger Proteins +18

Genome-wide specificity of DNA binding, gene regulation, and chromatin remodeling by TALE- and CRISPR/Cas9-based transcriptional activators

Lauren R. Polstein, Pablo Pérez‐Piñera, D. Dewran Koçak et al. · Genome Research · 2015 · 128 citations · Full text

Genetics, Molecular Biology, Epigenetics +23

Bidirectional approaches for optogenetic regulation of gene expression in mammalian cells using Arabidopsis cryptochrome 2

Gopal P. Pathak, Jessica I. Spiltoir, Camilla Höglund et al. · Nucleic Acids Research · 2017 · 67 citations · Full text

Arabidopsis Cryptochrome 2, Genetics, Molecular Biology +17