Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes

Kazuhiro Hasegawa, Shu Wakino, Petra Šimić, +12

Nature Medicine

Diabetic AlbuminuriaUrologyRenal Tubular Sirt1Renal FunctionMedicine +7

High Basolateral Glucose Increases Sodium-Glucose Cotransporter 2 and Reduces Sirtuin-1 in Renal Tubules through Glucose Transporter-2 Detection

Hiroyuki Umino, Kazuhiro Hasegawa, Hitoshi Minakuchi, +6

Scientific Reports

PPARγ in the endothelium regulates metabolic responses to high-fat diet in mice

Takeshi Kanda, Jonathan D. Brown, Gabriela Orasanu, +5

Journal of Clinical Investigation

β-hydroxybutyrate attenuates renal ischemia-reperfusion injury through its anti-pyroptotic effects

Takaya Tajima, Ayumi Yoshifuji, Ayumi Matsui, +6

Kidney International

ApoptosisRenal InflammationCell DeathOxidative StressInflammation +22

NNMT activation can contribute to the development of fatty liver disease by modulating the NAD + metabolism

Motoaki Komatsu, Takeshi Kanda, Hidenori Urai, +10

Scientific Reports

Peroxisome Proliferator-Activated Receptor γ Ligands Inhibit Rho/Rho Kinase Pathway by Inducing Protein Tyrosine Phosphatase SHP-2

Shu Wakino, Kôichi Hayashi, Takeshi Kanda, +5

Circulation Research

Vascular ToneCellular PhysiologyOxidative StressRho KinaseReceptor Tyrosine Kinase +15

Rho‐kinase as a molecular target for insulin resistance and hypertension

Takeshi Kanda, Shu Wakino, Koichiro Homma, +7

The FASEB Journal

Skeletal Muscle CellsHypertensionInsulin ReceptorMetabolic RemodelingInsulin Signaling +18

Gut<i>Lactobacillus</i>protects against the progression of renal damage by modulating the gut environment in rats

Ayumi Yoshifuji, Shu Wakino, Junichiro Irie, +6

Nephrology Dialysis Transplantation

Pioglitazone Lowers Systemic Asymmetric Dimethylarginine by Inducing Dimethylarginine Dimethylaminohydrolase in Rats

Shu Wakino, Kôichi Hayashi, Satoru Tatematsu, +7

Hypertension Research

Effect of fasudil on Rho-kinase and nephropathy in subtotally nephrectomized spontaneously hypertensive rats

Takeshi Kanda, Shu Wakino, Kôichi Hayashi, +3

Kidney International

HypertensionRenal FunctionMedicinePhysiologyChronic Kidney Disease +7